Geochemically fingerprinted widespread tephra layers serve as excellent marker horizons which can directly link and synchronize disparate sedimentary archives and be used for dating various deposits related to climate shifts, faulting events, tsunami, and human occupation. In addition, tephras represent records of explosive volcanic activity and permit assessment of regional ashfall hazard. In this paper we report a detailed Holocene tephrochronological model developed for the Kamchatsky Peninsula region of eastern Kamchatka (NW Pacific) based on ∼2800 new electron microprobe analyses of single glass shards from tephra samples collected in the area as well as on previously published data. Tephra ages are modeled based on a compilation of 223 14C dates, including published dates for Shiveluch proximal tephra sequence and regional marker tephras; new AMS 14C dates; and modeled calibrated ages from the Krutoberegovo key site. The main source volcanoes for tephra in the region are Shiveluch and Kliuchevskoi located 60–100 km to the west. In addition, local tephra sequences contain two tephras from the Plosky volcanic massif and three regional marker tephras from Ksudach and Avachinsky volcanoes located in the Eastern volcanic front of Kamchatka. This tephrochronological framework contributes to the combined history of environmental change, tectonic events, and volcanic impact in the study area and farther afield. This study is another step in the construction of the Kamchatka-wide Holocene tephrochronological framework under the same methodological umbrella. Our dataset provides a research reference for tephra and cryptotephra studies in the northwest Pacific, the Bering Sea, and North America.