We report, here, the composition and Ksingle bondAr ages of a representative collection of volcanic rocks that erupted within three monogenetic volcanic fields in the active fault zone of the Sredinny Range of Kamchatka: Tigilsky Dol, Mount Oxi massif and Anaunsky Dol. The studied rocks display a wide range of compositions (medium-K, moderate-Mg, high-K, high-Ti and high-Mg basalts, and high-LREE picrobasalts); the high-Mg varieties are confined to faults. Five main periods of volcanic activity were investigated, 4.3–3, 2, 1.5, 1 Ma and from 0.3 to <0.05 Ma. Primitive lavas first emerged on the surface at 3.5 Ma. There was a massive outpouring of high-Mg lavas at 1.5–1 and 0.3 Ma, which could have been related to the formation of the fault zone. This is the first report of rocks in Kamchatka with a high-LREE picrobasaltic composition (1.5 Ma). The Fo content of the olivine phenocrysts reaches 93.2 mol%, which is the highest value known for Quaternary Kamchatka basalts. A very heterogeneous source, even for individual eruptions is indicated by the minor element contents in the olivine (Ni, Mn and Ca); Cr-spinel – olivine paragenesis show that all the rocks studied crystallized in the same temperature range (1111–1292 °C), whereas the oxygen fugacity for the different samples varied from ΔQFM +0.7 to +2.0 log. units. A melt inclusion study showed that the Mg basalts of the Mt. Oxi massif and the high-LREE picrobasalts of Tigilsky Dol had different fluid sources that were enriched and depleted in water and Cl, respectively. We argue that the fluid source for the Mt. Oxi massif was likely the remains of the Pacific slab under the Sredinny Range, whereas, for the high-LREE picrobasalts of Tigilsky Dol, it was the lithospheric lithologies. The low content of S and high content of Cu in the oxidized high-LREE basalts provide additional evidence that they originated from the re-melting of sulfur-poor lithospheric lithologies. Both the fault zone and the lithosphere re-activation in the region are likely linked to the regional stress field.